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Hazard ratios comparing DFS, EFS, and OS between subgroups were calculated using univariate Cox models.
Hazard ratios for probability of relapse between subgroups were calculated using univariate Cox models.
The analysis of progression-free survival (PFS) and overall survival (OS) was done using the Kaplan-Meier method and differences between subgroups were calculated by log-rank test.
Survival curves were obtained using the Kaplan-Meier method and comparisons between subgroups were calculated by Breslow test (generalised Wilcoxon test).
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Significance of differences between subgroups was calculated using the log-rank test.
To describe differences in the distribution of antibiotic subgroups between countries, age-group-specific proportions of antibiotic subgroups were calculated for each database in the year 2008 based on the respective total number of systemic antibiotic prescriptions per age group.
To provide an explicit overview of the interrelationships between covariates and subgroups, unstandardized means and standard deviations of covariates in the respective subgroups were calculated: values were obtained by weighting raw data with the estimated posterior probabilities [ 42, 43].
For the subgroup analyses, impacts for each subgroup were calculated, and an H-statistic was generated to assess whether the difference in impacts between subgroups was statistically different.
Means and standard errors for each MT isoform and subgroup were calculated.
Adjusted subgroup effects were calculated for the three specified subgroups from the multiple logistic regression model.
To assess differences between subgroups, P values for interaction by using linear regression models including interaction terms of the group allocation subgroup variable were calculated.
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