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The classification presented here shows relations between subclasses of labeled digraphs, such as de Bruijn graphs, DNA graphs and others, and their connection with adjoints and quasi-adjoint graphs.
Thus, the broad phenotypic differences between class 1 and class 2 disease stem from genetic differences while the differences between subclasses of class 1 disease might be related to the presence of additional mutations or the occurrence of EPAS1 mutations during embryonic development or later in life.
As demonstrated by cross-species similarities in relative expression ratio of orthologous genes between subclasses (Supplementary Figs. 4 and 5 online) and measurable phenotypes (Fig. 3), mimicry of the mouse models of subclasses of human HCC may, to a large extent, be due to the similarity in the underlying biology of the disease.
The identities of the expressed receptors were confirmed using a panel of monoclonal antibodies that distinguish between subclasses and allotypes of FcγRIII and the cell lines were shown to have slightly higher levels of receptor than FcγRIII-positive peripheral blood mononuclear cells.
For LEfSe analysis, the alpha value for the factorial Kruskal Wallis test among classes and the alpha value for the pairwise Wilcoxon test between subclasses were set to 0.05.
High mutual enrichment (low p value) indicates a strong molecular correspondence between subclasses in different datasets.
Similar(34)
2. Case 2 (between-subclass): if vertex i and j belongs to different sub-class r and s at a height h, respectively, without loss of generality, a new vector k is added to sub-class r.
Because the raw tree with human peptide acetylation was built by complete hierarchical cluster method, adding any given different samples to the tree is unable to change the between-subclass relationships of the previous samples at any given height.
We selected the top 500 genes that are differentially expressed between subclass A and subclass B. We calculated and compared relative average gene expression ratios between subclass A and subclass B in each species.
We started to identify the most differentially expressed genes between subclass A (n = 41) and B (n = 50) in the human data set.
We used independent t-tests to select orthologous genes that had significant differences in expression between subclass A and subclass B in both species (P < 0.05 in both t-tests) and yielded 329 genes.
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