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The authors were contacted if additional unpublished data were needed; any overlap between study populations was avoided.
Interestingly, socioeconomic characteristics explained some of the variation in functional limitations between populations but two major health behaviours, smoking and drinking, did not seem to mediate the effects of socioeconomic characteristics, and their contribution to explaining some of the differences in functional limitations between study populations was limited to women.
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Possible overlaps between study populations were considered.
The largest difference between the two study populations was found for the disagreement between the self- and proxy-reports on the "self-esteem" dimension (β = 5.1).
The most notable difference between the two study populations was related to whether the patients receiving osteoporosis therapy were excluded.
The explanation for the differences in behavior of the placebo groups between the two studies is unclear because the patient populations are similar with the same entry criteria and only a small difference in BMI between the two study populations was noted.
HSV-2 prevalence of the study populations was between 23.7 and 34.5% by Focus HSV-2 ELISA (Table 1).
The mean age of the study populations was mostly between 75 79 years.
Variations between local study populations are not an insurmountable barrier for pooling data across sites, if they somehow can be accounted for [ 7, 8].
For example: if the difference in mean age between two study populations is lager than 5 years, age is considered an important factor according to the results of the AQUILA.
The most likely explanation for differences in carriage rates between the two study populations is the somewhat better socioeconomic status in our urban/peri-urban WA community than that on a remote island in the NT, also reflected in the higher prevalence of OM and CSOM in the NT community than in our study population [ 4, 5].
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