Supplementary Figure 6 Comparison of CDTS between study populations.
Pairwise Fst estimates based on candidate directional selection loci also demonstrated increased levels of differentiation between study populations.
Alternatively, microvascular alterations represent differences in underlying pathology between study populations.
An important consideration, therefore, is that of publication bias, which is where studies with statistically significant results are more likely to be published, and published earlier, than studies with no significant difference between study populations [29, 30].
Attrition of the original samples (through non-response and death) is another potential limitation and may account for some differences between study populations found.
In addition to the variation we observed in the proportion of atypical MBCs between study populations in the U.S., Peru, and Mali, we found significant differences in the proportions of other B cell subsets (Fig. 3).
This association was not replicated in a second population of middle-aged participants from the US, which may be partially attributed to differences in ethnicity, in mean age between study populations, or in differences between cognitive tasks used [6].
In contrast to a wealth of hypotheses brought up during recent decades, local adaptation appeared to be independent of the considered plant life-history traits, the degree of spatial and temporal habitat heterogeneity, and of the geographic distance between study populations.
There were differences between study populations.
Possible overlaps between study populations were considered.
61 Spectrum bias is the skewing of test parameters due to differences between study populations.
