Direct comparisons between study outcomes are to be considered with caution due to the range of definitions of cure and improvement reported.
The interaction term was significant for four out of five outcomes (HbA1c goal, LDL-C goal, LDL-C testing, and diabetes-related visits), indicating that the association between CCIGs and study outcomes was modified by visit frequency.
In Phase 3, the relationship between the CBPR model components and study outcomes was analysed using the conceptual logic model, which comprises four dimensions: context, group dynamics (including structural, relational, and individual sub-dynamics), intervention, and outcomes (9, 58).
Indeed, a net negative confounding effect explained why, after adjustments for these (and other) confounders, the adverse associations between HMGB1 and study outcomes were strengthened and became statistically significant.
The primary study outcomes are between-group differences in age and gender adjusted BMI Z-score and waist-to-height ratio at 12 weeks.
Accordingly, the estimated association between tegaserod use and study outcomes is not biased by differential outcome ascertainment, since the absolute incidence of study outcome is underestimated by a similar magnitude in the tegaserod and comparator cohorts.
The reason for this discrepancy between in vitro and clinical study outcomes is unclear.
Adjusted ORs and 95% CIs for associations between maternal glucose and HAPO study outcomes are in supplemental Table A. ORs are for the difference in glucose between the mean glucose value and the recommended threshold.
The associations between geohelminth infection markers and study outcomes are shown in Table 5. Children with anti- Ascaris IgE had a higher prevalence of recent wheeze (adj. OR 2.24, 95% CI 1.33 3.78, P = 0.003) and asIgE (adj. OR 5.34, 95% CI 2.49 11.45, P < 0.001).
Study outcomes were compared between the cohorts using standard bivariate and multivariable methods.
