No difference between the study groups could be observed concerning condom use and withdrawal (coitus interruptus).
Multiple regression analyses showed, that the determined differences of XER and XERcomp activity between the study groups could not be explained by the two selected POP proxy markers alone neither in combination with the measured potential confounders in the present study.
That age and weight differences between the two study groups could have somewhat influenced the results cannot be completely excluded, but because the age and weight were not correlated with CgA, as tested in the 64 healthy bitches, a notable effect on the results presented here is not expected.
For the "other sources of bias" domain, we regularly looked for baseline imbalances between study groups that could have biased the results or that were not accounted for; inappropriate influence of funders that could have biased the results; and early stopping for benefit.
The drugs could be Dextran-40, Mannitol, Aspirin, Citicoline, Venoruton, Defibrase, Sodium ozagrel, et al. As long as the conventional treatments were the same between study groups in one RCT, the RCT could be included.
Additionally, DNAm patterns within CpG enrichment classes or gene features could overshadow findings between study groups if probes are not separated and considered within these genomic features.
This was an observational study; therefore, we could not control for all differences between study groups.
In the present study we used different methodology and could not observe significant difference as to any of the above cited molecules between studied groups.
Although we determined that one major socioeconomic factor (number of bedrooms) was similar between cases and controls, there were significant differences in some demographic and socioeconomic variables between the two study groups, which could potentially affect effectiveness of the vaccine.
