a Central venous pressure significantly differed between groups (p < 0.001) and changed over time (p < 0.001), without interactions between study groups and time of assessment.
Primary analysis will compare the incidence of the composite primary outcome between study groups and will be by intention-to-treat.
Finally, alanine transaminase was 29.7 ± 9.8 and 34.6 ± 7.8 IU/L in the control and treatment group, respectively (p = 0.006), without significant changes over time, and no interactions between study groups and time of assessment.
As for additional pulmonary parameters, arterial partial pressure of carbon dioxide significantly increased during the study time (p = 0.001), without differences between study groups, while there were no significant differences between study groups, no significant changes over time, and no interactions between study groups and time of assessment in lung elastance.
There were no significant differences between study groups, no significant changes over time and no interactions between study groups and time of assessment in mean arterial pressure (c); cardiac output (d); systemic vascular resistance (e); and mixed venous oxygen saturation (f).
Ratio of partial pressure arterial oxygen and fraction of inspired oxygen (PaO2/FiO2) (e) and pulmonary shunt (f) significantly changed over time (p < 0.001 and p = 0.018, respectively), in a similar fashion between groups, and without interactions between study groups and time of assessment.
