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Optimisation of moment constrains to minimise differences between study data and survival curves predicted by the model.
It applies various measures for quality assurance, the most important being systematic plausibility checks as well as on-site monitoring with systematic comparisons between study data and patient files [ 10, 35].
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The likely reason for the difference between the study data and the national data is likely to be due to the small numbers of NMS recorded in this study.
Another possible reason for the difference between the study data and national data is that all the pharmacies sampled were in the same geographical location (Nottingham) and the demographics could potentially be different to demographics nationally.
The differences between our study data and theirs might be explained by the more lenient criteria they used for defining normal grip strength, which perhaps underestimated the numbers of individuals with subnormal grip strength.
Inter-group Chi-square testing was used to distinguish, statistically, between study data as regards patient gender distribution and independent-sample T test was used to distinguish between study data as regards patients' follow-up time and age.
There did not appear to be statistical differences between the current A/H1N1 study data and equivalent data collected for other medical conditions in relation to depression or death anxiety.
We report estimates from analyses pooling individual study data, and assessed between-study heterogeneity by calculating Cochrane's Q and I based on the per-study estimates, using the package meta, version 2.1-2 withen the R software, version 2.15.2.
A parallel can be drawn between making study data publicly available and publishing a paper itself in an open-access journal.
Recruitment and collection of study data took place between July 2009 and June 2011.
The Japan Public Health Center-based prospective study (JPHC study), data collected between 1990 and 2010.
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