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Overlap between study bases was avoided, and for this reason the first PM study, of Kirkcaldy rural (landward) district (Kinlen, 1988), was excluded, as it was largely covered by Glenrothes in the study that followed of British new towns (Kinlen et al, 1990).
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Comparisons between studies based on setting are drawn where appropriate in the discussion.
Another key difference between studies based on physical interventions and biobank research is that it is inherent in the nature of a biobank that the use of the samples is not tied to delimited start and end times of a particular piece of research.
Restricting the meta-analysis to the three studies based on Caucasians, between-study heterogeneity was less evident (Cochran's Q=3.1, P=0.21, I 2 =35%).
The between-study heterogeneity was assessed using the Chi square based Q-statistic [ 22].
23 We specifically identified outcomes for which meta-analyses of observational studies showed nominally significant associations (at P≤0.05), did not have large between study heterogeneity, were based on evidence from more than 500 cases (or more than 5000 total participants if the type of metric was continuous), and showed no evidence of small study effects or excess significance.
Reasons based upon heterogeneity (or between-study variation) were the most commonly cited (46/69; 66.7%).
Statistical heterogeneity between studies was assessed with χ2 based Q test, and the heterogeneity was considered significant when P<0.10 [25].
Therefore comparing the responsiveness between tests in the same group of patients all undergoing surgery for CTS is more appropriate than between studies, as it is based on the interpretation of the relative magnitude of ES or SRM rather than the absolute values.
In the stratified analyses, similar results were observed between subgroups according to study base, and significant association was found only for Africans.
The calculation of energy density of foods strongly differs between studies and can be based on all foods consumed.
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