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We conclude that i) IM hCG injections into male eels may be preferable over IP injections, ii) that 11KT implants can only partly mimic the effects of hCG in male eels in vivo, and iii) that hCG dose-response designs hold promise to evaluate treatment effects and compare between studies from different research groups.
A systematic review and synthesis of qualitative studies of GPs' attitudes to clinical guidelines found several common themes but no pattern of variation in attitudes between studies from different countries [ 6].
Other factors may be important (clinical, demographic, economic, and workplace) in explaining the great variance in the results of sick leave after carpal tunnel release between studies from different countries.
GPs follow clinical guidelines to varying degrees across practices, regions and countries, but a review study of GPs' attitudes to guidelines found no systematic variation in attitudes between studies from different countries.
Drawing items from existing tools and comparison of reliability results with the original tool has been encouraged [ 33] as it will facilitate comparison between studies from different regions, helping to draw robust conclusions about park characteristics and health behaviours or outcomes.
The results from that study were similar to a previous study using conventional radiographs [ 7], where intraobserver agreements generally were moderate, but interobserver agreement was poor, sometimes even less than a chance, making the authors question the reliability of comparisons between studies from different centers.
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Comparisons between different studies from different countries are controversial due to substantial disparities in economic, demographic, cultural and institutional (health sector) structures [ 45].
To some degree, the reproducibility and robustness of cellular and synaptic phenotypes in different Mecp2-mutant mice is difficult to evaluate owing to the methodological differences between studies published from different laboratories, and because not all available mouse models have been systematically analyzed.
Many of the differences in allelic diversity between VNTR locus studies from different areas are likely due to the population differences in the regions from which the M. tuberculosis strains were isolated or to different sampling times.
This heterogeneity may have arisen from differing methods of management between the studies, or through including studies from different time periods.
Random effects models are more robustly generalisable as they assume variability not only within studies but also between studies, a relevant assumption when studies from different populations are integrated to account for sampling error and population variance.
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