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This opens a new and exciting area to study on the correlation between structure and activity of P450scc and CYP27A1 and CYP27B1 generated active vitamin D3 hydroxyderivatives Since these compounds also differ in the presence or absence of a hydroxyl group at C-25, we suggest that a C-25 hydroxyl group, in addition to C-1 (see above), is necessary for strong induction of CYP24 gene expression.
Drug design and development aim to achieve a good correlation between structure and activity.
However, the understanding of their clear relationship between structure and activity is difficult and insufficient.
Docking simulation and the QSAR study was conducted for learning about binding mode and the relationship between structure and activity.
Tropsha now develops models to test the relation between structure and activity of drug candidates and studies protein folding and the effects of mutations on protein structure.
It would be very difficult for the model to properly establish any link between structure and activity dependence with such scarcity of information on both aspects.
Similar(42)
Finally, several aspects of the structural activity relationships are discussed in terms of the contribution of different bonds to the anticancer activity, thereby making the relationship between structure and biological activity more transparent.
The relation between structure and biological activity is also true for the antiviral activity of Hep/HS, which can also be modulated by varying the degree of epimerization, sulfation, or/and the chain length (Chen et al. 1997; Rusnati et al. 2009).
The relationship between structure and antiviral activity was also discussed.
The relationship between structure and inhibitory activity was also preliminarily discussed.
In order to understand the relationship between structure and catalytic activity, the spent catalysts were also analyzed by all physico-chemical methods.
More suggestions(15)
between passivity and activity
between performance and activity
between relaxation and activity
between baseline and activity
between structure and morphology
between architecture and activity
between structure and mayhem
between structure and flexibility
between transportation and activity
between structure and form
between structure and weather
between structure and architecture
between structure and reaction
between sleep and activity
between count and activity
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