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The distribution of HPV types were compared between specimen types and the occurrence of multiple high-risk infections examined.
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In such a way it can be established if different patterns in HPV type positivity are found between the specimen types and therefore between screening defaulters and attenders.
Subsequent quantification was equivalent between techniques and specimens, and differences between specimen types in several experiments were <0.5 log10 copies/mL.
Assay sensitivity varied between specimen types, as shown in Table 1.
They were less similar between specimen types with the average correlation coefficients of 0.45, which was likely due to the dominant effects on the RNA related to the tissue processing for FFPE specimens and/or the different hybridization techniques during DNA microarray analyses.
Differences were found in the odds of detecting multiple high-risk HPV infection between specimen types (p = 0.016) with fewer multiple infections detected in self-taken samples in line with the reduced sensitivity of these collection methods (Self taken swab OR = 0.61 (95% CI: 0.4, 0.96); Urine OR = 0.60 (95% CI 0.37, 0.98)).
The association between initial confirmatory specimen type and follow-up HIV-infection status remained statistically significant when stratified by whether initial confirmatory test result was negative or indeterminate (data not shown).
Table 1 illustrates study characteristics that differed between included studies, with studies differing by design, enrolment criteria, specimen type, and specific HI method.
The specimens types and number of tested specimens are shown in Table 3.
The reduced model showed a linear effect of SIMD (p = 0.00071) and of urban/rural residence (p = 0.0014) and a difference between the specimen types (p < 0.0001).
Evaluation of the AE and DIC data indicated distinct differences between the specimen types with respect to the time sequence of damage growth resulting in macroscopic failure.
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