Studies have demonstrated a relationship between the presence of specific polymorphisms in cytochromes CYP2B6, CYP2A6, and CYP3A4 and a higher risk of neuropsychiatric toxicity that is associated with the discontinuation of efavirenz [14]; however, there is no evidence of a different interaction of lamivudine and emtricitabine with efavirenz.
Our study of HIV evolution over time in five ethnically diverse populations perhaps most clearly demonstrates the broader importance of the correlation between HLA and subtype-specific polymorphisms in HIV Gag.
Using PHH spheroids from donors with specific polymorphisms, e.g. in ABCB11 encoding BSEP, might constitute an opportunity to investigate patient-specific risk factors in the development of drug-induced cholestatic liver injuries.
The inter-specific polymorphism between cultivated and wild species (33.4%) was higher in contrast to that of intra-specific polymorphism in the desi and kabuli genotypes (28%).
In order to further understand the functions of the porcine CA3 protein in muscle, the temporal and spatial distributions of its gene product were analysed and the association between the presence of specific polymorphisms and carcass traits in the pig was also examined.
This suggests that although GRA2 expression is necessary for full accumulation of p-IκBα to the PVM, it is likely due to proper parasitophorous vacuole biogenesis rather than the specific polymorphism present in GRA2 between RH-ERP and GT1.
Clearly, absence of evidence of an association between a specific polymorphism and endometriosis does not rule out that this gene in general or other polymorphisms of this gene in particular may be involved in the etiology of this disease.
The present study aimed to identify an association between a specific polymorphism, rs2226896 (for convenience and to distinguish it from the seven polymorphisms on which we reported previously, we refer to this variant as SNP8) and AD, in AAs.
The frequency of specific polymorphisms differs between ethnic groups and this led Dorne to assign different pathway-specific uncertainty factors in different ethnic groups [ 80].
Among the 63 polymorphisms, 26 were singletons almost exclusively found in two varieties: Kywet Thwar (9 specific polymorphisms), and Firooz (13 specific polymorphisms) with one in Thee Htat Pin Khine and two in Bu Saba.
