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Exact(5)

A better understanding of the correlation between specific mutations and tumor biology could offer insight for developing more target-specific therapies for patients with retinoblastoma (Fig. 4).

In addition, these databases do not allow for potential relationships between specific mutations and key melanoma histologic parameters to be explored.

11,18-20 Mofthef the mutations are located in the extracellular portion of the protein, but no clear correlation has been observed between specific mutations and clinical features.

In conclusion, our work contributes to the implementation of the available CPVT mutant models, which is mandatory for establishing a direct relationship between specific mutations and the observed functional effects, as well as determining potential side effects and is fundamental for validating such findings in the perspective of customized patient treatment.

However, there is currently no consensus due to the absence of correlation between specific mutations and clinical outcome, whether the initial choice of a MDR/XDR-TB drug regimen, pending the results of culture DST, should be based on the results of rapid molecular drug-resistance diagnosis.

Similar(55)

Both, on the basis of literature data and those presented here, however, no clear correlation has emerged between specific mutations in PTPN11 and the occurrence of cancer.

The variation in the identity of driver mutations is in keeping with the stochastic nature of myeloid leukaemogenesis, yet the identifiable patterns of co-occurrence and mutual exclusivity between specific mutations hint respectively at molecular synergy and redundancy between them (The Cancer Genome Atlas Research Network, 2013).

Second, epistatic interactions occur between specific mutations [ 46, 47, 49], and in some cases these can be mutually exclusive; for example, a strain harboring an rpoA mutation does not then also acquire an rpoC or additional rpoB mutations [ 6, 50, 51, 62].

Second-site noncomplementation (SSNC) tests between autosomal deficiencies (or specific mutations) and Rho1E(br)246 were performed by mating eight to ten Rho1E(br)246/CyO, P{w+, ActGFP} virgin females to eight to ten deficiency– or specific mutation bearing heterozygous males in vials.

33– 36 Interestingly, the clinical correlation between the presence of specific mutations and therapeutic response to TKIs is mirrored in cell lines and EGFR-transfected cells.

However, since the significance disappears when the heterozygous animals are included a simple relationship between a specific mutation and the susceptibility to EE is not present.

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