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Previous reports have suggested a positive association between specific genotypes and PML.
Instead of systematically testing the effects of known compounds -- the pharmaceutical industry's basic model for more than a century -- scientists can now investigate backward, combing through genomic data to find links between specific genotypes and diseases and then screening drug data to identify therapeutic candidates.
Other researchers are looking for associations between specific genotypes and disease phenotypes.
2 3 However, for this strategy to succeed, there must be a predictable relation between specific genotypes and disease expression.
Therefore, this approach is a powerful means of identifying links between specific genotypes and cardiac disease predisposition, as also recently demonstrated for neurodegenerative disease (Reinhardt et al, 2013).
Though there is still controversy about the biological relevance of these SNPs, there appears to be an association between specific genotypes and mRNA expression, P-gp expression and/or P-gp function (reviewed in [ 5, 6]).
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Moreover, phylogenetic studies indicated an association between specific genotype and the severity of the disease (8, 12 ).
This would be in concurrence with the observation that susceptibility and resistance to the infection varies between specific genotypes [42], [43].
A linear regression was fitted to the defined models to test the relation between specific genotype models and expression values.
One study did not find an association between any specific genotype and pneumonia.
The use of molecular genetic methods to analyze the population structure of Mycobacterium tuberculosis has enabled data to be collected on the relationship between a specific genotype and its influence on the course of disease [ 2, 3] with the outcome of disease being determined to a large extent by the individual characteristics of the patient and the genetic type of the mycobacterium [ 4].
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between specific disorders and
between specific SCCs and
between specific bases and
between specific nuclei and
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between specific characteristics and
between specific stimuli and
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between specific exposures and
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between specific locations and
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