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In contrast, the larger proportion of genome with reproducible but low biochemical signal strength and less evolutionary conservation is challenging to parse between specific functions and biological noise.
However, growth is a complex phenotypic trait with a highly polygenic basis such that it would be risky at best to attempt any further causal links between specific functions and variation in growth.
As the association between specific functions and branches of the 'Tree of Life' was continually put into doubt by LGT, many scientists were inadvertently forced to question whether 16S rRNA gene-based molecular tools could answer their questions.
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Specific technologies provide specific functions and have specific data requirements.
The regulatory interactions between the segment-specific functions and their respective target promoter follow a color code (Figs. 1 and 2).
Correlative SAR can establish new relationships between specific biochemical functions and higher-level cellular processes, particularly for proteins with multiple functions and small molecules with unknown or various modes of action.
Furthermore, the current study shows the utility of correlative SAR to establish links between specific protein functions and cellular phenotypes.
This approach allows for the study of direct links between specific cognitive functions and risk of conversion to AD from MCI.
This report also provides an example of how correlative SAR can help establish new relationships between specific biochemical functions and higher-level cellular processes by providing a quantitative way to link the effect of small molecules at the cellular, molecular, and atomic level.
In addition, the present analysis documents significant plasticity between the specific functions of individual nucleases in different organisms.
The relation between certain modules and specific functions, e.g., in metabolic networks [13], helps us to understand how different functions are coordinated in the integral performance of complex biological networks.
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