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As a consequence, questions such as whether there are differences in trade-offs between side effects and prolonging life between young and old people cannot be answered.
We quantitated degree of the associations between side effects and protein domains by evaluating the weights on the corresponding pharmacogenomic features.
We also emphasize that physicians prescribing pirfenidone should repeatedly and carefully consider the balance between side effects and the efficacy of pirfenidone in slowing lung function decline [ 11].
A balance needs to be made between side effects and tolerability and safety issues compared with clinical benefit and QOL (Kozman et al 2006).
To assess the relationship between side effects and adherence, individual logistic regression models were fitted for each side effect controlling for patient characteristics.
Thus, the relationships between side effects and the parent-rated therapeutic response are not likely due to common biological mechanisms, but are more an effect of the parental evaluation itself.
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A clear distinction between side effect and master-switch aspects of miRNA regulation is very difficult and certainly beyond the scope of the present report.
GPs discussed the balance between side-effects and vaccine effectiveness: If there are a lot of mild or some serious side-effects, while the effectiveness is maybe not all that high, then I think, yeah, then you should not do this.
For example, Pope & Scott [ 6] distinguish between side-effects and fear of side-effects informing decision-making and Basco & Smith [ 14] suggest that a memory of unpleasant side-effects might inform an affective rather than reasoned response.
Interestingly, for Whites expectation of "pain relief" was the more salient and consistent factor, whereas African-Americans traded between "side-effects" and "pain relief" suggesting unique concerns underlying analgesic taking behavior and possibly disparate clinical management of pain and side-effects between the two groups.
Side effects were dichotomized (hot flushes: grade 0 1 vs. 2 3, other side effects: grade 0 vs. grade ≥1), and the difference between side effects before and at 2 months of dose escalation were tested using the McNemar's Chi-squared test.
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