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ATP is a significant signaling molecule in the PNS, as it plays an important role in chemical communication between several cell types [ 26, 27].
The wound healing process of acute wounds is an intricate interplay between several cell types involving various forms of intracellular signalling and classical wound healing phases like haemostasis, inflammation, and new-tissue formation.
Along these lines, it was demonstrated in a series of studies that an interplay between several cell types in the CNS was ultimately responsible for the pruning of synapses by microglia in the visual system.
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The Opa proteins have different binding affinities to heparan sulphate and CD66-family proteins and are able to cause intimate adhesion between meningococci and several cell types, as well as influencing binding of capsulate bacteria [54] [60].
Some studies have reported the relationship between periostin and MMPs in several cell types.
It is also likely that a successful response results from the synergistic activity of several cell types, given the interaction between RGCs and other retinal cell types that are reported to assist in a positive injury response.
Microvesicles (MV) are extracellular vesicles sized between approximately 100 nm and 1 µm that are released by several cell types upon stimulation or apoptosis [9, 10].
Gene knockout and transplant studies have revealed a cross-talk between the stroma and the epithelium (both compartments themselves consist of several cell types).
The exclusive link between RIP1 and NF- κB activation has now been challenged because several cell types from RIP1-deficient embryostillll activated NF- κB upon TNF stimulation.
Synergy between TNF-α and IFN-γ to induce CXCL10 has previously been reported for several cell types, including leukocytes, epithelial cells, endothelial cells and fibroblasts [ 13- 16].
There are several cell types essential for mammals to navigate.
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