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The relationship between sequence complexity and disorder propensity provides further insight into the structural and functional variations of IDRs.
The regression line between normalized hydrophobicity and complexity is read as (2) x Φ - μ Φ σ Φ = ρ c, Φ x c - μ c σ c Note that ρ c,Φ is the correlation between sequence complexity and hydrophobicity.
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Shamil Sunyaev, Division of Genetics, Dept. of Medicine, Brigham & Women's Hospital and Harvard Medical School This manuscript investigates differences in sequence complexity and hydrophobicity between transmembrane helices serving purely structural role and transmembrane helices with additional functional roles.
Our study also highlighted poor concordance between FF and FFPE somatic variants in regions of sequence complexity and regions with reduced read mappability.
Those with low sequence complexity and higher hydrophobicity will be called 'simple' TMs; we define those with high sequence complexity and lower hydrophobicity as 'complex' TMs.
Preliminary analysis on five reference genomes has revealed a significant correlation (p< = 0.05) between sequence length and complexity, with longer proteins showing more low complexity regions.
Coverage by large repeats varies considerably within grasses and underlies substantial changes in sequence complexity between relatively recently diverged taxa (e.g., Oryza and Bambusa) as well as subspecies (Fig. 2) and genetic lines [2] of maize.
Also, sequence complexity between the probes was meant to be similar, since it is well established that the rate of reassociation depends on sequence complexity [ 14].
Romero, P., Z. Obradovic, X. Li, E.C. Garner, C.J. Brown, and A.K. Dunker, Sequence complexity of disordered protein.
Finally, sequences were examined for interspersed repeats and regions of low sequence complexity using RepeatMasker.
To further flag difficult alignments in homo- and dipolymer runs as well as short simple sequence repeats, sequence complexity was defined by different triplets around the focal position.
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