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However, none of them showed correlation between sequence changes and oligomerization, except for the αF helix.
While the effects of some sequence changes, such as the gain or loss of a stop codon, are predictable, the overall relationship between sequence changes and gene structure remains unresolved.
The only trend between sequence changes and disease phenotype is that most cases of GSS include 129V on the mutant allele, but the presence of this polymorphism in some familial CJD cases diminishes the correlation.
Similar(56)
First, we used the method of Pagel et al [ 52, 108] which quantifies the proportional contribution of punctuated and gradual (g) evolution to path lengths in a phylogeny, based on extent of association between sequence change and cladogenesis events.
The analysis was carried out using linear mixed models incorporating correlations between sequence changes within the same protein and proteins within the same individual.
There are three nucleotide differences between 3p05p and 3p, which introduced both sequence changes and mismatches between the two halves of the stem.
Also consistent with previous results [15], we observed no association between sequence change overall ('All hexamers' in Figure 1A, essentially comparing identical with non-identical exons).
Previously, evidence was found of a correlation between the rate of nucleotide sequence change and the rate of gene rearrangement [ 26].
There are no consistent sequence changes between JJW and AV95, although there are hot spots where amino acid changes occur more frequently in both subjects, especially in the V1 region (see green highlighted amino acids in the alignment below).
To assure artifact-free transitions within a sequence, changes between gratings and plaids were implemented by a dynamical color table assignment method.
Sequence changes between assemblies CM3.5 and CM3.6.1 in each R-gene region (start to stop codon, including introns).
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