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For enzymatic proteins, the well-studied relationship between sequence and function allows us to translate genomic information into relatively concise functional predictions [ 6- 8].
K-mer-based classification is a powerful approach to detect recurrent relationships between sequence and function in lncRNAs.
A QSAR regression model on the relationship between sequence and function suggests that in this peptide type the patterns KXQQ and KXEE are favorable, whereas Ala residues appear to have an inhibitory effect.
This makes a correlation between sequence and function especially demanding.
As Zeldovich et al. point out, many evolutionary models lack any causal connection at all between sequence and function [8].
These are obviously approximations and notably, a recent study failed to support a correlation between sequence and function conservation [ 23].
Similar(46)
This review demonstrates how recent advances in ultrahigh-throughput screening, mutational scanning, DNA synthesis, metagenomics, and machine learning will soon make it possible to model, predict, and manipulate the relationship between protein sequence and function, accelerating the tailor design of novel biocatalysts.
Although few explicit assumptions about the complex relationship between protein sequence and function are required, the results are dependent on the accuracy and completeness of the training data.
Owing to the tight correspondence between opsin sequence and function, opsins are an excellent system for the study of molecular adaptation [ 8].
Rational methods including site-directed mutagenesis are preferred but such approaches rely on a detailed preinsight into the relation between the sequence and function, which is typically not the case for most promoters.
Though enzymatic function can be inferred by sequence and structure similarity, the relations between sequence, structure and function are far from being completely understood.
More suggestions(15)
between sequence and synteny
between art and function
between sequence and expression
between style and function
between expression and function
between architecture and function
between sequence and array
between modesty and function
between form and function
between structure and function
between sequence and amyloidogenicity
between sequence and stability
between sequence and methylation
between microstructure and function
between sequence and pHMM
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