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The central limitation is that this deamination requires a very strong oxidising agent, which in the reductases involves intermediates between selenium esters and the deaminated glycine [ 32] (in principle an analogous bond could be established by thioesters).
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Also, there are interactions between selenium and other minerals, such as zinc and copper.
There are interactions between selenium and other nutrients, such as iodine and vitamin E. The effect of selenium deficiency on health remains uncertain, particularly in relation to Kashin-Beck disease.
Interaction between selenium and lead concentrations were not significant, and the putative protective effect of selenium through antioxidative properties was not confirmed in this study.
This systematic review assessed the association between Selenium intake and metabolic syndrome.
In June, the agency updated its position, saying that there is limited credible evidence for a relationship between selenium supplements and a reduced risk of prostate cancer.
Epidemiological studies have suggested an association between selenium intake and protection from a variety of cancer.
Odds ratios were calculated for sliding windows at constant amount of selenium concentration data points to determine the relationship between selenium concentration and disease risk.
The relationship between selenium status and thyroid goiter was examined by univariate and multivariate logistical regression.
Analyses also point towards a gene-environmental interaction between selenium exposure and GPX1 polymorphism.
There appears to be an association between selenium levels and risk of lung cancer [ 25].
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