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The researchers firstly studied the association between selected polymorphisms in key transporter proteins related to vitamin C and vitamin A concentrations and POAG.
Our research does not support an independent association between selected polymorphisms in the VDR, GC, or CYP24A1 genes and postmenopausal breast cancer risk among US Caucasian women.
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We investigated interactions between treatment and selected polymorphisms in the CYP17 and CYP19 genes, both of which are involved in the sex hormone biosynthesis pathway, and the oestrogen receptor (ESR1) gene.
It is also essential to carry out molecular analyses that identify location of selected polymorphisms, functions of genes in which selected polymorphisms are located, and effect of selected polymorphisms on gene functions.
We selected polymorphisms of the known distribution in the European population.
The genotypic frequencies of selected polymorphisms were compared between the controls and depressed subjects.
The selected polymorphisms were genotyped in 680 cases and 593 controls from the Czech Republic.
The full list of genes and selected polymorphisms is outlined in Table 1.
We have not found association of the PPARG selected polymorphism with obesity in this population.
Table 2 shows the results found in the selected polymorphisms.
Fisher's exact test was used to evaluate the differences between healthy volunteers and patients with malignant melanoma in the frequency distributions of genotype of the selected polymorphisms.
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