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This approach was taken as it was not feasible to draw blood samples more frequently and yet it was desirable to try to determine the time to PC90 that likely occurs between sampling time points.
Still, no significant differences (P > 0.05) in bacterial diversity indices (Inverse Simpson (1/D) and Shannon diversity (H′)) were observed between sampling time points.
For instance, in a study of retinoic acid teratogenicity, compound-induced transcriptome changes differed between sampling time points (Robinson et al. 2012b).
Changes in concentration or estimated mass of compound in the body reflect the net effect of both elimination and any ongoing exposures between sampling time points.
In total, there were 82 blood-Hg measurements taken at two different time points that were separated by at least a two-fold difference and of these, 27 (33%) decreased between sampling time points while 55 (67%) increased.
In addition, it is reported by Costa to be insensitive to the shapes of dissolution profiles and does not put into consideration unequal spacing between sampling time points [ 23].
Similar(51)
With HI assays, using longer time intervals between sampling time-points substantially reduced the number of seroconversions detected.
In cases where change was observed, this was typically a brief (i.e., between two sampling time points) transition between genotypes previously recovered from that colony and/or endemic to that particular reef (Table 4, Fig. 2).
There was no significant change in P. falciparum prevalence between the two sampling time points (66% vs. 62%) but a few people moved between infection status; 36 people remained negative, 68 positive while 9 people changed status from positive to negative and 4 from negative to positive.
However, because no known major disturbance events have occurred between the two sampling time points at Ribbon Rf 5, our interpretation of the results is that they reflect independent bouts of recruitment, the Ribbon Rf 5_2003 population possibly from outside the reef.
The women lived near a chlorinated chemical plant that ended operations in 2003, between the two sampling time points.
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