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An alternate or contributory factor leading to the difference in allele frequency between sample types, as well as to the mutational disagreements between FFPE and CTC samples, may be the inherent heterogeneity of individual CTCs which were pooled for WGA from each patient [ 43].
Similar(59)
IBC and DCIS sample populations were considered separately in order to determine if any patterns existed in the mutation load of the individual sample types as well as to discover the presence of any interactions between the two tissue types.
Testing of reduced dimension variables, such as the total REE content, similarly exhibited no differences between sample types.
We found no difference between sample types.
However as opposed to what they report, we did not find modulation of the distribution between sample types, even when considering all the samples from the TCGA dataset.
It was encouraging to find generally a good correlation between the two sample types, as one concern was that alternative splicing of MUC1 might reflect changes induced by culture.
On the contrary, our comparative analysis on the different sample types as shown by the Venn diagram clearly demonstrated high fidelity in gene expression with a high degree of overlap (88 94%) between the PAX and PAX-GR samples.
Vary your sample types as appropriate.
Between sample type, biopsies or stools, quantitative and qualitative differences were observed.
Fisher's exact test was used to analyse association between sample type and LRP1 expression level.
However, no modulation was observed between samples types.
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