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We assume that positions with such conservation pattern account for differences in the specificity between proteins from different specificity groups.
Comparison is made to the OMA methodology, which also identifies one-on-one mapping between proteins from different species.
Our data suggest that heterologous seeding events between proteins from different species might mimic a crossing of the species barrier.
Some common allergen cross-reactivities have been explained by sequence/structural similarities between proteins from different sources.
A basic implementation of this concept takes as input multiple interaction networks along with the similarity relationships between proteins from different species.
In contrast, the NTDs and CTDs were poorly conserved and there was little sequence similarity even between proteins from different dipteran families (Additional file 1: Figure S1A).
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The median genetic interaction between proteins from two different complexes was compared to the median of 10 6 equal-sized random samples of genetic interactions.
Amino acid differences between homologous proteins from different species may have adaptive significance, as is the case with gastric lysozymes.
Both of them belong to the OS-E/OS-F group (Fig. 5) and display the highest identity between orthologous proteins from different mosquito species (Table 2).
In this way, we obtain a statistical significance score for each pairwise sequence alignment between orthologous proteins from different species.
This tool calculates evolutionary conservation scores between homologous proteins from different species and maps them on a given three-dimensional protein structure.
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