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The model studies evolutionary changes in these thermodynamic parameters, and we invoke relations between these activation variables and structural properties of the protein to predict the following correspondence between protein structure and folding kinetics.
The relationship between protein structure and function: A comprehensive survey with application to the yeast genome.
However, due to the complex nature of allosteric mechanisms, a clear and predictive understanding of the relationship between protein structure and allosteric function remains elusive.
Better understanding of the links between protein structure and function will underpin the development of an increasing number of engineered biopharmaceuticals in the future.
The correlation between protein structure and function is well established, yet the role stability/flexibility plays in protein function is being explored.
Generation of novel protein functions is a major goal in biotechnology and also a rigorous test for our understanding of the relationship between protein structure and function.
Similar(38)
Therefore, in the future, more detailed knowledge about the relationship between protein structures and functions, as well as advancements in high-throughput technology, may greatly expand the capabilities of protein engineering.
The analysis pipelines in Gerontome are useful to predict regulatory networks of homologous genes, docking simulations between protein structures and ligands, and protein interaction networks.
We present a coarse grained model to explore the interplay between protein structure, folding and function which is applicable to allosteric or non-allosteric proteins.
In addition, to identifying these sub-states, the motions associated within the sub-states and inter-conversion between the sub-states provide new insights in to the inter-relationship between protein structure, motions and function.
Before discussing details, we should examine the underlying connections between static protein structure and dynamical protein functions.
More suggestions(17)
between gene structure and
between protein structures and
between protein size and
between protein polarity and
between song structure and
between protein corona and
between protein diffusion and
between protein synthesis and
between isochore structure and
between protein conservation and
between protein homology and
between landscape structure and
between processing structure and
between protein concentration and
between chemical structure and
between protein Sso7d and
between firm structure and
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