Sentence examples for between promoter methylation and from inspiring English sources

We further interrogated the correlation between promoter methylation and expression of VILIP-1 in 21 primary human NSCLC.

Nevertheless, there is a large body of evidence that MethyLight assays provide an excellent correlation between promoter methylation and gene silencing in similar tumor settings [11], [29].

The discrepancy between promoter methylation and a lack of MGMT immunoreactivity argues for assessing MGMT promoter methylation both by immunohistochemical as well as by molecular approaches for diagnostic purposes.

To explore the relationship between promoter methylation and gene expression in primary tumours we performed a qRT-PCR analysis of SOX9, HOXA9, AHR, ROBO1, and NR2F2 in a series of 36 MCL.

Furthermore, statistical analysis of expression and promoter methylation (n = 150 primary NSCLC samples) showed a significant relationship between promoter methylation and protein expression downregulation as well as between survival and decreased or absent VILIP-1 expression in lung cancer tissues (p<0.0001).

The data presented in Figure 9D are consistent with our previous observations of the relationship between promoter methylation and gene expression (without considering CpG frequency) based on data obtained using both the Agilent array and Infinium arrays (Figure 8A,B,C).

Further studies of promoter methylation and 3' UTR evolution will be needed to uncover the underlying mechanisms of the connection between promoter methylation level and the number of miRNA target sites.

We also analysed the relationship between promoter methylation status and basal expression levels of RAR-β, RAR-β2, MGMT and SYK in GCTs of ovaries.

However, the discrepancy between promoter methylation and MGMT negativity necessitates combined immunostaining and methylation specific PCR.

Correlation study between promoter methylation extent and clinicopathological parameters is shown in dataset S3.

Alternatively, a larger sample size may facilitate the ability to define a closer association between promoter methylation status and expression in these genes.