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CsA trough levels alone do not seem to discriminate between progressors and nonprogressors.
The baseline characteristics of subjects were summarized and compared between progressors and nonprogressors by a two-sample t test or a Wilcoxon rank sum test.
This may be an explanation to the finding of no significant difference in mean telomere length between progressors and nonprogressors in our study.
In this analysis we did not find any difference in mean telomere length between progressors and nonprogressors, neither in the whole material, nor when analysing only non-dysplastic, diploid lesions.
For baseline characteristics, categorical variables were compared by a Pearson χ test, and continuous variables were evaluated by t test for the differences in means or by the Wilcoxon rank-sum test for differences in order between progressors and nonprogressors.
Krupa et al. [ 52] identified two miRNAs in human renal biopsies, the expression of which differed by more than twofold between progressors and nonprogressors with respect to DN, the greatest change occurring in miR-192 which was significantly lower in patients with advanced DN, correlating with tubulointerstitial fibrosis and low glomerular filtration rate.
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Univariate general linear modeling was used for comparisons between progressor and nonprogressors to type 2 diabetes during a mean of 6 years of follow-up for the main variables measured during the 4-year follow-up.
Still we found a significant difference between progressor and nonprogressor cases (p = 0.014).
Overall we found a significant difference in the amount of ultra short telomeres between progressor and nonprogressor colons (p < 0.001).
In qualitative terms, age and education did not differ between progressors and non-progressors, although women made up a larger proportion of the progressors (Table 1).
Future progressors had already developed metabolic complications by the time they entered stage 3 CKD, despite no differences in initial eGFR between progressors and non-progressors.
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