Sentence examples for between preclinical data and from inspiring English sources

This dissociation between preclinical data and clinical reports raises uncertainty for the treating clinician.

The discrepancy between preclinical data and clinical outcomes is believed to result from the less pronounced enhanced permeability and retention (EPR) effect in and the heterogeneity of human tumors as well as the intrinsic/acquired drug resistance to monotherapy over the treatment course.

The reasons for the discrepancy between preclinical data and our clinical results are unclear.

The disparity between preclinical data and clinical studies can be attributed to various factors, including differences in pharmacokinetics, pharmacodynamics and metabolism, as well as a failure to accurately model the tumour microenvironment (Becher and Holland, 2006; Gopinathan and Tuveson, 2008; Sharpless and Depinho, 2006; Zhang et al., 2013).

One of the major issues in drug development is the absence of correlation between preclinical data and trial results leading to failure of multiple phase III studies, in part due to the poor predictive value of cell line studies [ 19, 20].

These trials are an important link between the preclinical data and the most common use of TMR TMRR + Coronary Artery Bypass Grafting).

Possible explanations for the discrepant results between the preclinical data and the clinical data include HCC tumor heterogeneity both in humans and model systems.

Although preclinical data and an early clinical trial suggested synergy between gp100 vaccine and CTLA4 blockade [38], this could not be confirmed in this large RCT.

This review aims to provide insight in advanced experimental and mathematical modeling approaches using preclinical data, and proposed steps to be taken for translation between conditions and ultimately to species translatability for nose-to-brain transport in humans.

But most preclinical data and basic research data will be voluntary.

A good model needs to be based on clinical or preclinical data and its improvement needs to make use of available clinical and preclinical testing of predicted data.