In order to investigate the reproducibility of eQTL between independent mouse populations, we compared the number of eQTL common between the MDP and BXD datasets to the number of common eQTL obtained with randomized data.
To find other genetic discrepancy between the CHS and CHB populations, we compared the dynamic information, including the major/minor alleles and indels [ 41].
To gain more information about potential changes in transcription between control and Huwe1 knockdown cell populations, we compared gene expression profiles of these two cell types by RNA-seq analysis.
To glean further details of the genomic regions contributing to the genetic similarity between European Jews and the perspective populations, we compared their total genomic regions shared by IBD.
Among the treatment naïve populations, we compared baseline characteristics between those who did and did not receive treatment.
Thus, when comparing the results of GWA studies between different populations, we compare only a small fraction of the total genetic risk present in each population, leading to many seemingly population-specific signals.
To determine if intron profiles were related to population structure, we compared intron content between each population (Table 2).
However, the snails grew larger when fed on plants from between-population crosses compared to when feeding on within-population crosses.
On average, snails grew larger when fed on plants from between-population crosses compared to plants from within-population crosses indicating lower resistance of plants from between-population crosses, and therefore outbreeding depression (Table 1, Fig. 1b).
For randomized populations, the F ratio for between-population variance compared with within-population variance was close to one for each of the climate variables at all months of the year.
