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Rather than assumptions based on an ad-hoc selection of one or two studies, these pooled estimates (together with the measure for variability between populations) should be used as an input in future cost-effectiveness analyses of RV vaccination.
This would imply that differences between populations should be driven by positive selection to new environmental conditions.
The above hypothesis predicts that most expression differences between populations should be the result of changes occurring within the European population during colonization.
Therefore, estimates of R should be interpreted in the context of the population under study and the season in which data was collected and direct comparisons of R between populations should be undertaken with caution.
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Furthermore the pooled (global) estimates, in combination with an extra measure of uncertainty to account for variability between studies (populations), should be used as an input in future CE analyses of RV vaccination rather than an ad-hoc selection of one or two of the studies we identified.
Therefore, comparison between different populations should be carefully addressed.
When the heterogametic sex is female, mitochondrial transmission between diverged populations should be impeded: as pointed out by Mallet [ 38] this may explain why mitochondrial introgression is more common in mammals and flies than in birds and bees [ 39].
The variability between species and populations should be studied so that uncertainty and applicability may be estimated.
Future studies aimed at explaining differences in plant behaviour between P. australis populations should be careful in the selection of target genotypes and/or populations, and should avoid generalizing their findings beyond the genotypes and/or populations studied.
Nevertheless, although there are a number of reasons for the discrepancies between studies devoted to the association between CD209 single nucleotide polymorphisms and development of tuberculosis, but confounding host, bacterial, and environmental factors between different study populations should be taken into account.
The unequal distribution of sexes between the low and high altitude populations should be noted, however it is not statistically significant.
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