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As we did not observe a large effect it seems that an association between polymorphisms of other TLR genes and RA and/or a functional role for TLR genes in the pathogenesis of RA would be weakly predictable.
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We do not understand how polymorphisms reflect a disease and/or respond to a treatment, or if they react in conjunction with polymorphisms of other genes.
Regardless of the discrepancy in TNFSF11, we and the others [ 29] both found a strong association between polymorphisms of TNFRSF11A and AANM.
Association between polymorphism of the insulin receptor gene and migraine provided inconclusive results.
Complicating assessment of TNF-α polymorphisms is the high degree of linkage disequilibrium between TNF-α promoter polymorphisms and between other polymorphisms within other nearby genes, many of which also have significant inflammatory roles.
Further studies are required to establish the significance of the positive association between the -308 polymorphism and vascular invasion, including the study of other polymorphisms in angiogenic genes, which are thought to be important in solid cancers [ 35].
No association between these polymorphisms and other phenotypes was found.
It may be that the non-significant association between the DRD3 MspI polymorphism and non-ergoline DA treatment discontinuation is indicative of other polymorphisms not studied in this gene region.
Yang, S.-J. et al. Relationship between genetic polymorphisms of ALDH2 and ADH1B and esophageal cancer risk: a meta-analysis.
There was a significant association between combined polymorphisms of 5-HT1A and BDNF polymorphisms.
We also compared the frequencies of other polymorphisms of the mtDNA CR (besides T16189C) between the control and disease populations.
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