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An inverse correlation between pericyte coverage and hematogenous spread has also been observed in colorectal cancer patients [37].
We then examined the relationship between pericyte coverage and the seeding of 4T1 tumour cells.
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However, the difference between overall pericyte coverage and pericyte coverage of embolised vessels was less marked for RENCA cells than it was for 4T1 cells (compare Fig. 2d with Fig. 2e).
Moreover, NDPK-B deficient retinas showed a significant decrease in pericyte coverage and an increase in formation of acellular capillaries mimicking the pathology of early stage diabetic retinopathy (DR).
In vivo, transplantation of BM-VPC with decreased Dll4 into tumor-bearing mice resulted in the formation of microvessels with decreased pericyte coverage and reduced fibronectin expression.
Vessel stability and maturity were also assessed by pericyte coverage and angiopoetin 1(associationiation [ 18].
During angiogenesis there is co-migration of pericytes with EC sprouts [ 116- 120] and concomitant proliferation of migrated cells before renewed pericyte coverage and termination of angiogenesis [ 59].
Capillaries that underwent regression had the same pericyte coverage and apparent structural maturity as capillaries that survived.
Endothelial pericyte coverage and vascular permeability have been suggested as factors contributing to increased tumor metastasis [ 24].
In the subcutaneous model, Irinophore C™ restored the basement membrane architecture, increased the pericyte coverage and reduced blood vessel diameters.
Tumor vessels in the periphery display greater pericyte coverage and angiopoetin 1 association than vessels in the tumor center.
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