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However, these types of pathways will add noise to the pattern between pathway length and timing of gene loss from the neo-Y, which will make testing this prediction more difficult.
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A possible relationship between the proteolytic pathway length, influencing the concentration of active Cry toxin fragments, and the favourable membrane potential for the epithelium permeabilization is schematically shown in Figure 9B.
Simulations were conducted to evaluate the performance of D and UD under different sample sizes, pathway effect and pathway length.
These two methods both require predefining the pathway structure and pathway length.
Other aspects influencing the pathway performance are pathway length, organism specificity [ 38], heterologous expression, growth rate, and precursor supply [ 44].
Moreover, longer pathway lengths stress pathway conservation more, and will inevitably miss some interesting short pathways.
By integrating pathway structures, we unravelled the association between pathway structures and drug sensitivity.
No statistically significant correlation was found between exon length and CDS length (Fig. S2).
A correlation exists between cMS length and mutation rate.
(E ) Relationship between intron length and retention.
For the first time, we determined the relationship between telomere length and tumour progression and location, as well as its relationship to MSI and p53 mutation status, two markers of major pathways of genetic instability in CRCs.
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