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Some previous studies have focused on a potential interaction between parity and age.
Given the high correlation between parity and age at first birth, it is difficult to tease apart their individual effects.
The assessments of synergism between parity and age at menarche, age at natural menopause, height, and BMI are presented in Table 4.
Multivariable conditional logistic regression, conditioned on age and sex, was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) as measures of the association between parity and age at first birth in relation to risk of oesophageal cancers.
A case control study, nested within a nation-wide Fertility Register covering Swedish women born 1925 and later, was undertaken to explore possible associations between parity and age at first birth and the risk of renal cell cancer.
Given the strong inverse correlation between parity and age at first birth among controls (r=−0.66, P<0.0001), we examined their joint effect on gallbladder cancer among women with stones (Table 2).
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We observed interaction between parity and gestational age, process of birth and referral respectively.
The proportional hazard assumption was tested by checking the statistical significance of the product term between parity and attained age.
Interaction effects between parity and, subsequently, maternal age, process of birth and moment of referral were also examined with logistic regression analysis.
These findings indicate that associations between the reproductive factors parity and age at first birth, and risk of EA might not be explained by sex hormonal influence.
In an analysis restricted to parous cases and age-matched parous controls, the OR for CMV seroconversion for IgG between the two samples, adjusted for parity and age at first birth, was 9.7 (95% CI=1.2 77.3).
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