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For example, a close association between oxidative capacity and the levels of the myosin heavy chains I and IIa has been reported [56], [57], [58].
However, once the fibres were divided into their respective fibre types, two species lost their respective strong relationships between oxidative capacity and CSA.
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However, the link between mitochondrial oxidative capacity and insulin resistance remains inconclusive and requires further research.
10 Further, a positive correlation has been observed between mitochondrial oxidative capacity and insulin sensitivity in lean and obese young adults 27, 28 and in sedentary and exercise-trained older adults.
However, when comparing the oxidative capacity and fiber size between type IIA and type I fibers, literature shows less distinctive results.
Given the link between physical inactivity and muscle fibre shift, this probably reflects reduced quadriceps oxidative capacity and endurance, leading to early fatigue.
In obese individuals, skeletal muscle oxidative capacity and responsiveness to insulin are impaired [100].
Enzymatic changes may affect mitochondrial oxidative capacity and ATP synthesis.
Mitochondrial dysfunction, including decreased oxidative capacity and increased oxidative damage, is thought to substantially contribute to biological aging.
The former have a high oxidative capacity and high demand for O2 delivery, while the latter have a lower oxidative capacity and a reduced demand for O2[ 17].
A low oxidative capacity of skeletal muscle has been associated with reduced fat oxidative capacity and greater risk of developing obesity, insulin resistance and/or type 2 diabetes.
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