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This effect is two-fold larger than other sources of differences between our laboratory groups, either sexual dimorphism, response to food consistency or divergence among strains.
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Furthermore, this work would not have been possible without a constant exchange of data and molecules between our laboratory and several groups at BMS, and Alicia Regueiro-Ren was instrumental in orchestrating this multifaceted research.
Our protocol has wide applications, not least the ease of transfer between species and laboratory groups globally.
We must be expeditious in drug development, which will ultimately lead to more robust preclinical testing of compounds and better concordance between laboratory groups.
We report how many of these re-sampled data sets result in a significant difference between the wild and laboratory groups at p<0.05.
Previous assessments of glutamate-stimulated state 4 and 3 mitochondrial oxygen consumption (VO2) through complex I in our laboratory showed no difference between age groups [ 18].
Recent work in our laboratory studied the genetic relationship between members of Group II C. botulinum using a whole-genome DNA microarray.
However, previous studies from our laboratory have demonstrated activation differences between high gF and low gF groups in interference-control regions [5].
Cytocompatibility studies and the interaction between BNNTs and living cells have only been reported recently [21, 22] by our group and other biomedical applications concerning their magnetic properties are actively under investigation in our laboratory.
Between-group (laboratory versus field) heterogeneity (Q-value) was tested by permutation.
Although this may not fully reflect the differences in sensitivities of different assays, it does allow a consistent comparison between different laboratories and groups of assay methods, without introducing any bias from the range of concentrations included in the assays.
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