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However, the geographical areas selected for randomization were chosen to avoid 'contamination' between our intervention groups by clearly separating them geographically.
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The comparison between our intervention group and control group is valid, because there were no significant differences in headache characteristics between both groups.
Our analysis found no significant post-intervention differences between the intervention groups.
To estimate the difference between intervention groups, difference between least-squares means and corresponding 95% CI were calculated based on the ANCOVA model.
Effect sizes for the various time point comparisons were variable with no consistent pattern within or between the intervention groups.
There were no statistically significant differences in perceived stress between the intervention groups.
RESULTS No significant differences between the two intervention groups, or between these intervention groups and the observational control group.
The difference between the intervention groups was not statistically significant at any time point (Table 5).
Also, the baseline concentrations of the biomarkers did not differ between the intervention groups.
Admission frequency or request of CT examination did not differ between the intervention groups regardless of CRP-level.
Consequently, treatment characteristics are similar between the intervention groups.
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