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These small p-values indicated the significant difference between our data set and the random cases.
The distribution of r's between our data set and the random case (see Methods for a derived closed form solution of the random case) clearly differed (Figure 1A).
Although low, the overlap between our data set and those previously generated (6.2%) was quite similar to the overlap between the previously generated data sets themselves (8.1%, [28]), and may reflect 1) the possibility that only a limited set of Oct4 targets are in proximity to a PORE sequence, and 2) potential low genomic coverage in our search.
In spite of differences in the identity of the comparison cell type, as well as platforms and assessment of significance of differential regulation, we found a significant overlap between our data set and all other studies (Figure 6 and Table 1).
These DEP comparisons provide evidence for significant concordance between our data set and those of previous studies.
Only one gene was found in common between our data set and those of Norelli et al. [ 11], Baldo et al. [ 12], and Sarowar et al [ 13].
Similar(39)
To ensure independence between our data sets, proteins from the test set (Uniprot) determined to be identical or subsequences of proteins in the training set (RefSeq) were removed from the test set.
Above these thresholds, correlation between our data sets was at acceptable values for reliable interpretation.
The largest genetic differentiation between populations in our data set existed between the Big Salmon River from the upper Yukon River and all other coastal populations.
Also, provided the value a exceeds the sum of the two greatest distances between points in our data set, the construction will always produce the 100% isopleth while keeping the radius of LoCoH elements small in high density regions of the data.
On the other hand, if a does not exceed the sum of the two greatest distances between points in our data set, then to obtain the 100% isopleth we need to specify that at least the two nearest neighbors are always included irrespective of the value of a.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com