We found a marked double dissociation between objective response and subjective confidence: instances in which subjects systematically responded correctly at very low confidence and others in which subjects responded systematically incorrectly with very high confidence in their response.
Figure 3 shows the results of correlation between objective response and TATO in 36 patients.
The intervals between objective response and local recurrence were less than 12 months in 5 patients (range, 2.6 to 9.7 months).
There was no relationship between objective response and weight loss for patients with either SCLC (P=0.3) or NSCLC (P=0.5) (Table 4 >).
Furthermore, 9.1% showed a change from M0 to M1 and 0% showed a change from M1 to M0. Figure 2 shows the results of the correlation between objective response and average TAIO in 36 patients.
A meta-analysis of metastatic breast cancer studies found a positive relationship between objective response and overall survival on an individual patient basis, but the relationship was less clear when treatment regimens were compared (Bruzzi et al, 2005).
There was no significant association between objective response rate and the angiogenesis-related proteins investigated.> There was a trend toward an association between better PFS with lower NOTCH1 expression (p = 0.06, Fig. 4a).
The subsequent analysis of large clinical trials has demonstrated a clear negative relationship between objective response rates and the occurrence of mutations in the KRAS gene, establishing KRAS mutations as negative predictors for EGFR-targeted therapies in mCRC (Amado et al, 2008; Karapetis et al, 2008; Lievre et al, 2008).
First line monochemotherapy, or more intensive regimens, reported overlapping activity and efficacy in phase III trials, ranging between objective response rate (ORR) 10 20.9% and overall survival (OS) 4 8.7 months [ 11, 12].
Based on the FEM results, RSM is used to establish a response model to depict the function relationship between the objective response and design variables.
