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In association with MCA, DEMOD analysis was performed and demonstrated a significant association between nuclear expression of ID2 and histological differentiation of NSCLC (Figure 2B).
These results were globally in agreement with our study, as we demonstrated a direct relationship between nuclear expression of ID2 and the survival of patients.
However, previous studies on breast cancer and SCLC have reported that high cytoplasmic expression of ID2 was associated with a good prognosis, whereas no correlation was found between nuclear expression of ID2 and the survival of patients [13], [22].
Significant association was observed between nuclear expression of Slug and loss of membranous E-cadherin [p = 0.001; OR = 4.49 (95% C.I = 1.82-11.8)].
In our melanoma cohort we did not find any association between nuclear expression of FABP7 and disease-free or overall survival.
The relationship between nuclear expression of Jab1 and the level of EGFR was assessed, together with the level of S100A7, because of the previously established strong relationship between S100A7 expression and Jab1.
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Importantly, there was significant correlation between the nuclear expression of YB-1 and cyclin D1 and cyclin A in the nucleus of OS cells (Table 2).
This study examined the correlation between high nuclear expression of hepatoma-derived growth factor (HDGF) and clinicopathologic data in endometrial carcinoma (EC), including patient survival.
A linear relationship was observed between increased nuclear expression of Snail and shortened survival (≤50%: 76.6 ± 2.7 months; 50 75%: 68.5 ± 2.0 months; ≥75%: 63.3 ± 2.8 months).
Studies investigating TFAP2α expression in human cancers show a correlation between reduced nuclear expression of TFAP2α and shorter recurrence-free survival and aggressive clinicopathological features in colon cancer [ 11], breast cancer [ 16], ovarian cancer [ 13] and melanoma [ 24].
No association was found between nuclear expression and age, tumour size or the presence of vascular invasion or between cytoplasmic expression and NPI.
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