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The differences between normal epithelial cells and established cancer cell lines were also plotted.
In this work we searched for genes that exhibit consistent differences in expression between normal epithelial cells and established cancer cell line cells.
Adhesion between normal epithelial cells is usually strong and stable, limiting cell movement.
HMGCR is differentially expressed among breast cancers, as well as between normal epithelial cells and tumor cells, with higher expression in the tumor cells.
An additional therapeutic window for MT201 may come from an engagement and sequestration of Ep-CAM within homotypic cell adhesion zones present between normal epithelial cells.
Variability in localization of GST pi between normal epithelial cells and tumor cells was reported by Forrester et al. [ 33]; further, in some of their samples, GST pi was almost absent from tumor tissue.
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The transition between normal epithelial cell biology and transformation into a malignant cell status can be defined histologically (Figure 2), as morphological changes developing hyperplasia, followed by dysplasia and a final diagnosis of carcinoma.
Figure 2b summarizes potential relations between normal epithelial cell types and commonly used models of mammary tumorigenesis.
Understanding the relation between normal epithelial cell types and the different molecular subtypes of breast cancer is fundamental to gaining insight into cell types predisposed to carcinogenesis.
Amongst the established cell lines there was no significant difference between fibroblasts, normal epithelial cells and Ras-transformed derivatives of the same normal epithelial cell.
Secondarily, it may be desirable, although not necessarily essential, to distinguish between cancer and normal epithelial cells.
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