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There was no statistical difference in mRNA expression for the vascular endothelial cadherin and occludin between normal endothelial cells and those from preeclamptic pregnancies.
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A major difference between BMVEC and normal endothelial cells is the tight junctions.
Whether this could depend on differential responses between tumor and normal endothelial cells has not been tested.
However, the very large difference in RGS2 expression between F19-depleted tumours and normal endothelial cells suggests that a pronounced therapeutic window for RGS2 targeting exists.
Comparative gene expression analysis revealed molecular differences between tumor endothelial cells and normal endothelial cells and identified novel tumor endothelial cell markers that may be exploited to target tumor angiogenesis for cancer treatment.
(7– 9) Differences between tumor endothelial cells (TEC) and normal endothelial cells (NEC) in aspects, such as gene expression and biological behavior, have also been reported.
Vascular endothelial cadherin expression for normal endothelial cells showed a continuous staining of the junctional protein that surrounded cell borders.
Here, we show significantly increased EGFL6 expression in tumor versus wound or normal endothelial cells.
Altogether, these results indicate that DMSA-Fe2O3 have some cytotoxicity that may cause side effects on normal endothelial cells.
NCAM was also found to be expressed on tumor endothelial cells while forming new capillary-like tubes, but not on normal endothelial cells.
PEI-g-1PEG-RGD also exhibited high specificity to angiogenic endothelial cells compared with normal endothelial cells, which was confirmed by in vitro transfection experiments with non-targeting PEI-g-1PEG-RAE in angiostatic endothelial cells.
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