Either way, since IQ seems both associated with the neurocognitive dysfunctioning as well as with ADHD behaviour, a mediating effect of IQ may be expected on the relation between neurocognitive dysfunctioning and ADHD.
In conclusion, we set out to determine the rate and nature of psychopathology and neurocognitive dysfunction, and the relationship between them, in children with 22q11.2DS.
Finally, we highlight the need for well-designed studies to develop and test interventions aimed at preventing and improving neurocognitive dysfunction and its sequelae after HCT.
Although 45 60 min of HCA is generally considered safe, neurologic complications include stroke, seizures, neurocognitive dysfunction, and delayed neuropsychomotor development.
By employing Home F/U, we detected 11 additional complications at 6 months: 1 major neurologic complication, 6 cases of neurocognitive dysfunction and 4 cases of functional decline.
There are several notable differences between Table 3 and Table 4. First, as a result of conducting Home F/U, we were able to document 1 new case of major neurologic morbidity, 6 additional cases of neurocognitive dysfunction and 4 additional cases of functional decline (n=11) (Table 4).
This is in line with previous studies on cognitive dysfunctioning in patients with ADHD, in which not all patients portray neurocognitive dysfunctioning and effect sizes are generally modest [ 71].
In light of the close connections between the basal ganglia and prefrontal cortex, 1 growing evidence has shown that non-motor symptoms may also be present in patients with PD, including neurocognitive dysfunction 2 and impairments in social cognitive function.
To unequivocally prove a causal relation between hypoglycemia and neurocognitive dysfunction, a prospective, randomized controlled trial would be required, but self-evident, ethical considerations preclude this approach.
