Sentence examples for between mutation and phenotype from inspiring English sources

Here we describe, in detail, the complementation experiments for mutant 7K, as one example of the direct link between mutation and phenotype.

Preliminary analyses of our M3 cad mutants (data not shown) indicate that the mutation is heritable, segregates and can be correlated with brown/orange coloured xylem further establishing the link between mutation and phenotype in the flax population.

As an alternative to embarking on such a programme, we instead assess the correlation between mutation and phenotype by comparing homozygous recessive mutants to heterozygotes and homozygous wild-type sibling plants in a segregating population for which the background mutations are the same.

Although some strains carry multiple unique nonsynonymous, nonsense, or frameshift mutations, the combined power of limiting the scope of the search based on genetic markers and of using a comparative analysis among the eighteen genomes provides strong support for the association between mutation and phenotype.

Computational methods have been used to identify disease similarities using a variety of data sources, including gene expression in cancer (Rhodes et al., 2004) and known relationships between mutations and phenotypes (Goh et al., 2007).

Thus, shifting the analysis to the systems level by considering the pathways and cellular functions affected might offer a more general view of the relationship between mutations and phenotypes, helping to detect common biological alterations associated with specific types of cancer.

At present, an apparent lack of correlation exists between genotype and phenotype in general and even within a family, and the relation between mutation and clinical phenotype can differ markedly between individuals [ 10].

Whether the associations between mutation position and phenotype are sufficiently strong to influence genetic counselling and management of affected families remains a moot point.

As the data from different studies are not consistent, we think that associations between mutation position and phenotype are not sufficiently strong to influence genetic counselling and management of individual families.

The result handout (Towle 1999) was modified to clarify the relationship between DNA alteration by mutation and phenotype change and to show that evolution means changes beyond generations (Fig. 4).

Previous studies on discrepancies between mutation and culture-derived resistant phenotypes suggest that molecular assessment may eventually become the reference standard for some drugs [ 51, 52].