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Probes with low intensity (<100) were excluded and each chip was median centred, based on the expression of the internal 100-probe 'reference set', a series of probes selected by Affymetrix based on their low variation between multiple tissue types.
Studies have confirmed correlation of PEG3 methylation between multiple tissue types, including blood and normal breast tissue [ 38] and that cancerous breast tumours have increased methylation compared to benign breast tumours [ 39].
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In order to be able to comment on whether there are significant topological (and hence potentially biological) differences between tissue types, we considered those nodes that appear in multiple tissue types.
In part, this is due to the difficulty of integrating and regulating multiple tissue types within artificial materials, which causes a gap between native skeletal tissues.
To more directly address the question whether sequencing from multiple tissue types improves the breadth of transcriptome coverage, orthologous genes between G. maderense and A. thaliana and between P. x hortorum and A. thaliana were identified.
Recent validation studies for primary diagnosis use the "broader scope" approach [ 52– 54], where diagnoses on multiple tissue types from multiple organs and using multiple stains are compared between optical and digital microscopy.
The formation of multiple tissue types and their integration into composite tissue units presents a frontier challenge in regenerative engineering.
Our observation may provide valuable information for exploring such relationship of multiple tissue types.
Taken together, RASSF1A and NF2 appear to be positive modulators that promote mammalian Hippo signaling in multiple tissue types.
Embryonic germ cells form embryoid bodies and subsequent embryoid body-derived (EBD) cells have the ability to differentiate toward multiple tissue types.
"In multi trauma incidents, maybe due to a blast, you might have to generate multiple tissue types," he said.
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