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Instead, the ability to clear a bacterial infection is likely to depend upon complex interactions between multiple host factors.
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It is noteworthy that outcome of the interaction between immune system and Mtb is shaped by multiple host factors, including age, diet, body mass index, genetic makeup, other chronic diseases or co-infections and exposure to environmental mycobacteria [65].
Recent work suggests a role for multiple host factors in facilitating HIV-1 reverse transcription.
Association between specific MHCI alleles and survival has been shown [ 7], which imply that a collection of multiple host factors may explain disease resistance.
Collectively, these results imply that optimal constellation of multiple host factors are explaining disease resistance.
Despite these limitations, RNAi screening of VACV-infected Drosophila cells has identified multiple host factors required for VACV entry in eukaryotic hosts (Moser et al., 2010).
Nef interacts with multiple host factors in order to optimise the cellular environment for virus replication [ 12].
Among the subgroup of Mtb-infected individuals that do progress to disease rapidly after initial infection or after a long period of clinical latency, there are dynamic and complex interactions that occur between multiple host and pathogen factors that must ultimately tip the balance towards disease occurrence.
Susceptibility to M. avium disease is poorly characterized; however, multiple host risk factors have been associated with M. avium infection.
To visualize the overlap of interactions between various host factors and microbial taxa, we constructed a network of associations between bacterial taxa and observed host and environmental factors.
This analysis revealed a web of complex overlapping linkages between numerous host factors and bacterial taxa.
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