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Here, considering the balance between molecular complexity and diversity for the molecules in the three studied datasets, Level 1 and Level 2 of the Scaffold Tree were used in our analysis.
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Minor structural differences between biosimilars and their reference product are expected and allowed because of their inherent molecular complexity and differences in manufacturing processes among biologics manufacturers [ 4].
Zamir, E. & Geiger, B. Molecular complexity and dynamics of cell-matrix adhesions.
Zamir, E. & Geiger, B. Molecular complexity and dynamics of cell matrix adhesions.
Multiple metrics have been developed to quantify molecular complexity and explore complexity property relationships.
Differences in molecular complexity and size are known to bias the evaluation of fingerprint similarity [3].
13321_2017_206_MOESM2_ESM.docx Additional file 2. The supporting information contains details on molecular complexities and on molecular morphing threshold optimization.
A similar asymmetry between the molecular complexity of antagonistic processes is also observed in cellular signal transduction where the repertoire of specific protein kinases (usually activating their protein target) is much larger than the number of relatively unspecific phosphatases [34].
The mas receptor mediated actions of Ang-(1 7) can also be influenced by AT2R-related mechanisms, suggesting a complex interaction between these receptors and highlighting the molecular complexity of this system [ 39].
The data show increased crystal misorientation with increasing side-group length and molecular complexity.
synthetic and molecular complexity metric.
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