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Melanoma cells display an inherent ability to switch between modes of migration [ 19, 20].
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Metastatic cells switch between different modes of migration through supramolecular plasticity mechanism(s) still largely unknown.
Further explorations of the commonalities and differences between distinct modes of migration will enhance our understanding of how neurons reach their final positions during development.
The observation that all RINs switch between different modes of migration is consistent with the observations of Noctor et al. (2004), who showed that most cortical neurons born in the ventricular zone switch from bipolar to multipolar modes of migration on their way towards the marginal zone.
Using chimeric analysis, we show that FBM neurons have two modes of migration: one involving interactions between the neurons and their planar-polarized environment, and an alternative, collective mode involving interactions between the neurons themselves.
PCP-dependent and collective modes of migration are likely to both be active during wild-type FBM neuron migration, as neither mode alone is sufficient for complete migration.
Cells exhibit three distinct modes of migration when invading the 3 D environment.
These multiple modes of migration are adopted by different cell types in different contexts.
Furthermore, modes of migration can vary substantially among tumor cells [ 25, 27].
In other articles in this issue, these different modes of migration are described in detail.
Students can switch between modes of study.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com